An effect of age on the phosphodiesterase activator protein of rat cerebral cortex. A brief note

Measurements were made of the effectiveness of phosphodiesterase activator protein isolated from the cerebral cortex of rats of various ages in stimulating the phosphodiesterase-catalyzed conversion of cyclic-AMP into 5'-AMP. An age dependent increase in the potency of preparations of activator protein was observed, with the activator isolated from animals six months of age and older being generally more efficacious than that from younger animals.