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Effect of ethanol on the induction of lung tumours by ethyl carbamate in mice
H J Altmann1, B Dusemund, M Goll
1Abteilung Toxikologie der Lebensmittel und Bedarfsgegenstände, Max-von-Pettenkofer-Institut, Berlin, Germany.
Abstract:
Groups of 25 female NMRI-mice received daily doses of 0, 18, 36, 90, or 180 mg ethyl carbamate/kg body wt either in water or in 20% ethanol by gavage for 8 weeks. Another 8 weeks later, the animals were sacrificed and lung adenomas were counted. Ethyl carbamate was found to increase the number of lung adenomas per mouse dose-dependently in all dose groups. No significant differences, however, were observed between groups receiving ethyl carbamate in water or in 20% ethanol. Thus, ethanol had no effect on ethyl carbamate induced tumourigenesis.
