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Granulocyte function in coronary artery disease.

S de Servi1, G Ricevuti, A Mazzone

  • 1Divisione di Cardiologia, IRCCS Policlinico S. Matteo, Pavia, Italy.

The American Journal of Cardiology
|September 3, 1991
PubMed
Summary
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Granulocytes, immune cells, can harm heart tissue by releasing toxic substances. Their altered function in ischemic heart disease contributes to conditions like myocardial infarction and angina.

Area of Science:

  • Immunology
  • Cardiology
  • Cell Biology

Background:

  • Granulocytes produce toxic substances to fight microbes.
  • Uncontrolled release of these substances can damage healthy cells and connective tissue.
  • Emerging evidence links granulocytes to myocardial ischemia pathogenesis.

Purpose of the Study:

  • To explore the role of granulocyte function in ischemic heart disease.
  • To investigate how granulocyte 'priming' and activation impact coronary events.

Main Methods:

  • Review of experimental and clinical investigations.
  • Analysis of neutrophil function in stable and unstable ischemic heart disease.

Main Results:

  • Altered neutrophil function is observed in various ischemic heart disease manifestations.

Related Experiment Videos

  • 'Priming' of granulocytes in stable coronary disease may precede acute events.
  • Neutrophil activation contributes to vascular changes and injury in acute myocardial infarction, unstable angina, and post-angioplasty.

    • Conclusions:

    • Granulocytes play a significant role in the pathophysiology of myocardial ischemia.
    • Modulating granulocyte function could be a therapeutic target for ischemic heart disease.