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Updated: Jun 28, 2026

The Soft Agar Colony Formation Assay
Published on: October 27, 2014
Wnt/beta-catenin pathway in hepatocellular carcinoma pathogenesis and liver physiology
Catherine Cavard1, Sabine Colnot, Virginie Audard
1Département Endocrinologie Métabolisme et Cancer, Institut Cochin, Université Paris Descartes, CNRS UMR 8104, Paris, France.
Abstract:
The Wnt/beta-catenin pathway is a key developmental pathway for which alterations have been described in various human cancers. The aberrant activation of this pathway is a major event in human hepatocellular carcinoma. Several laboratories have shown that the Wnt/beta-catenin pathway plays an essential role in all phases of liver development and maturation, and is required for the metabolic function of this organ. In this review, we summarize current knowledge regarding the role of the Wnt/beta-catenin pathway in hepatocellular carcinoma pathogenesis and liver biology, and the possibilities for developing new therapeutic interventions based on this knowledge.
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