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Diurnal temperature range as a novel risk factor for COPD death
Guixiang Song1, Guohai Chen, Lili Jiang
1Shanghai Municipal Center of Disease Control and Prevention, School of Public Health, Fudan University, Shanghai, China.
Background And Objective:
Although the relationship between day-to-day temperature changes and COPD mortality is well established, it is not known whether temperature variation within one day, that is diurnal temperature range (DTR), is a risk factor for acute COPD death, independent of the absolute temperature level.
Methods:
In a time-series study, the relationship between DTR and daily COPD mortality between 2001 and 2004 in Shanghai, China was assessed. A semi-parametric generalized additive model was used to allow for long-term and seasonable trends in COPD mortality, as well as variation in air pollution and weather.
Results:
There was a significant association between DTR and daily COPD mortality. A 1 degrees C increase in the 4-day moving average for DTR corresponded to a 1.25% (95% confidence interval: 0.35-2.15) increase in COPD mortality.
Conclusion:
These findings suggest that DTR is a novel risk factor for acute COPD death.
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