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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Other Disorders of Digestive System

The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
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Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...
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In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

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Gastrointestinal disorders in elderly patients.

A Reginelli1, M G Pezzullo, M Scaglione

  • 1Section of Radiology, Department Magrassi-Lanzara, Second University of Naples, Piazza Miraglia 2, 80131, Naples, Italy.

Radiologic Clinics of North America
|October 17, 2008
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Summary

Gastrointestinal disorders in elderly patients present unique challenges, differing from younger individuals. Radiologists play a key role in diagnosing and managing acute abdominal conditions in this population.

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Area of Science:

  • Geriatric Medicine
  • Gastroenterology
  • Radiology

Background:

  • Gastrointestinal (GI) disorders are highly prevalent in the elderly population.
  • Clinical manifestations, complications, and treatment strategies for GI issues in older adults often diverge from those in younger demographics.
  • Impairments commonly affect both the proximal and distal gastrointestinal tracts, including swallowing abnormalities and pelvic floor pathologies.

Purpose of the Study:

  • To highlight the unique aspects of gastrointestinal disorders in elderly patients.
  • To emphasize the diagnostic challenges posed by acute abdomen in this demographic.
  • To underscore the crucial role of radiologists in guiding management decisions for elderly patients with acute abdominal conditions.

Main Methods:

  • Review of clinical presentations and diagnostic challenges in elderly patients with GI disorders.
  • Analysis of common pathologies affecting the proximal and distal GI tracts and pelvic floor.
  • Focus on acute abdomen scenarios, including small bowel obstruction and mesenteric ischemia.

Main Results:

  • Elderly patients exhibit distinct GI disorder presentations and complications.
  • Swallowing difficulties and pelvic floor dysfunctions are frequent findings.
  • Acute abdomen in the elderly can present subtly, masking severe visceral pathology, posing diagnostic hurdles.

Conclusions:

  • Gastrointestinal disorders in the elderly require specialized consideration due to altered presentations and potential for severe underlying conditions.
  • Radiologists are integral in the diagnostic pathway, aiding in the identification of serious intra-abdominal pathologies and informing management strategies.
  • Early and accurate radiological assessment is critical for effective treatment of acute abdominal conditions in geriatric patients.