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A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
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Published on: June 26, 2020

Hepatitis B virus genotype E variability in Africa.

Judith M Hübschen1, Iris E Andernach, Claude P Muller

  • 1Institute of Immunology, Laboratoire National de Santé, L-1950 Luxembourg, Luxembourg.

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
|October 17, 2008
PubMed
Summary
This summary is machine-generated.

Genotype E, prevalent in sub-Saharan Africa, shows low genetic diversity, suggesting a recent introduction within the last 200 years. Its spread across the continent requires further study.

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Area of Science:

  • Virology
  • Genetics
  • Epidemiology

Background:

  • Genotype E is the predominant viral genotype across a wide region of sub-Saharan Africa.
  • Despite its extensive distribution and high prevalence, Genotype E exhibits remarkably low genetic diversity.

Purpose of the Study:

  • To review and analyze current understanding of Genotype E.
  • Re-analysis of all available S gene sequences and complete genomes of Genotype E.

Main Methods:

  • Phylogenetic analysis of complete genome sequences.
  • Comparative analysis of genetic distances across different geographic regions.

Main Results:

  • Phylogenetic analysis confirmed distinct South-West/Central African and West African sequence lineages.
  • The mean genetic distance for Genotype E was 1.71%.
  • Southern African countries within the Genotype E region showed lower genetic distances compared to Northern countries.

Conclusions:

  • Genotype E appears to have a longer evolutionary history in Northern sub-Saharan Africa than in the South.
  • The absence of Genotype E in the Americas suggests introduction into the African population within the last two centuries.
  • Further research is needed to elucidate the spread patterns of Genotype E throughout sub-Saharan Africa.