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Updated: Jun 28, 2026
08:50
5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
Published on: July 3, 2013
Hypertension-associated kidney disease: perhaps no more
Barry I Freedman1, John R Sedor
1Department of Internal Medicine, Section on Nephrology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1053, USA. bfreedma@wfubmc.edu
Journal of the American Society of Nephrology : JASN
|October 17, 2008
Summary
Essential hypertension
Area of Science:
- Nephrology
- Genetics
- Cardiovascular Disease
Background:
- The role of essential hypertension in end-stage renal disease (ESRD) pathogenesis is debated.
- Recent research highlights genetic factors in ESRD etiology, particularly in African Americans.
Purpose of the Study:
- To investigate the association between genetic variants in the nonmuscle myosin 2a (MYH9) gene and ESRD.
- To determine the contribution of MYH9 genetic variants to ESRD risk in African American populations.
Main Methods:
- Analysis of genetic variants in the MYH9 gene.
- Association studies with end-stage renal disease (ESRD) in African American patients without diabetes.
Main Results:
- A strong association was found between specific genetic variants in the MYH9 gene and ESRD.
- An MYH9 risk haplotype significantly contributes to the excess risk of ESRD in African Americans.
Conclusions:
- Genetic susceptibility, specifically related to MYH9 variants, plays a crucial role in the development of ESRD.
- Hypertension may lead to kidney disease only in genetically predisposed individuals or be secondary to primary kidney conditions.
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