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Related Experiment Video

Updated: Jun 28, 2026

Isolation and Culture of Cells from the Nephrogenic Zone of the Embryonic Mouse Kidney

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Published on: April 22, 2011

Podocyte-derived BMP7 is critical for nephron development.

Itsuro Kazama¹, Zhen Mahoney, Jeffrey H Miner

¹Division of Nephrology, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.

Journal of the American Society of Nephrology : JASN

|October 17, 2008

Summary

Bone morphogenic protein 7 (BMP7) is crucial for kidney development after initial nephron formation. Podocyte-specific BMP7 deficiency impairs proximal tubule growth, revealing a BMP7-dependent signaling axis essential for nephron maturation.

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Area of Science:

Developmental Biology
Nephrology
Molecular Biology

Background:

Congenital renal hypoplasia involves defects in nephron growth during development.
While genes for initial nephron induction are known, postinductive kidney development regulation is poorly understood.
Bone morphogenic protein 7 (BMP7) deficiency arrests kidney development post-induction, but its later role is unclear.

Purpose of the Study:

To investigate the role of podocyte-derived BMP7 in nephron maturation.
To elucidate the signaling pathways regulated by BMP7 during kidney development.

Main Methods:

Generation of a podocyte-specific conditional knockout of BMP7 (BMP7 CKO) in mice.
Analysis of kidney histology, glomerular basement membrane components, and cellular proliferation in BMP7 CKO mice.
Examination of downstream signaling pathways including Smad1/5/8, p38 MAPK, and beta-catenin.

Main Results:

BMP7 CKO mice exhibited hypoplastic kidneys and reduced proximal tubules with impaired proliferation.
Glomeruli showed normal laminin and collagen IV expression.
Decreased phosphorylated p38 MAPK and reduced, vesicular beta-catenin were observed in BMP7 CKO kidneys.
Phosphorylated Smad1/5/8 levels remained unchanged.

Conclusions:

Podocyte-derived BMP7 is essential for proximal tubule development and nephron maturation.
BMP7 signaling influences p38 MAPK and beta-catenin pathways during kidney development.
Results define a BMP7-mediated regulatory axis between glomeruli and proximal tubules in kidney development.