Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Fungi01:29

Overview of Fungi

1.3K
Fungi are a diverse group of eukaryotes more closely related to animals than other eukaryotes. Fungal cell walls comprise chitin, a polysaccharide that provides structural strength, and glucans, which contribute to flexibility and integrity. Other polysaccharides, such as mannans and galactosans, may supplement or replace chitin in some fungi. These adaptations, along with their preference for acidic environments and tolerance for high osmotic pressure, enable fungi to thrive in various...
1.3K
Fungal Phylum Basidiomycota01:26

Fungal Phylum Basidiomycota

688
Basidiomycota is a diverse phylum of fungi that includes ecologically significant decomposers such as white rot fungi, symbionts like mycorrhizal fungi, plant pathogens such as rusts and smuts, and edible species like Agaricus bisporus (the common button mushroom). These fungi play crucial roles in nutrient cycling, symbiotic relationships, and even human health. Their defining feature is the basidium, a microscopic club-shaped structure responsible for producing basidiospores.Fruiting Bodies...
688
Fungal Group Zygomycota01:29

Fungal Group Zygomycota

841
Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...
841
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

5.2K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
5.2K
Abnormal Proliferation02:23

Abnormal Proliferation

5.0K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.0K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

4.5K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fatty acid channelling into triglycerides and oxylipins drives ferroptosis resistance during oncogenic BRAF-induced senescence.

Cell death and differentiation·2026
Same author

MYC serine 62 phosphorylation promotes its association with DNA double-strand breaks to facilitate repair and cell survival under genotoxic stress.

Genes & development·2026
Same author

Riboflavin metabolism shapes FSP1-driven ferroptosis resistance.

Nature cell biology·2026
Same author

MondoA mediates transcriptional coordination between the MYC network and the integrated stress response in pancreatic cancer.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

MYC binding to nascent RNA suppresses innate immune signaling by R-loop-derived RNA-DNA hybrids.

Cell·2026
Same author

Corrigendum: A germline point mutation in the MYC-FBW7 phosphodegron initiates hematopoietic malignancies.

Genes & development·2025

Related Experiment Videos

Myc's broad reach.

Martin Eilers1, Robert N Eisenman

  • 1Institute of Molecular Biology and Tumor Research, 35033 Marburg, Germany.

Genes & Development
|October 17, 2008
PubMed
Summary
This summary is machine-generated.

The myc gene family, including c-, N-, and L-Myc transcription factors, plays a crucial role in cell biology. Recent studies reveal its expanded function in targeting genes and its involvement in stem cell and cancer development.

Related Experiment Videos

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • The myc gene family has been extensively studied since the 1980s for its role in normal and cancer cells.
  • Myc proteins function as transcription factors, regulating target gene expression.
  • Recent advancements have broadened the understanding of Myc's multifaceted roles.

Purpose of the Study:

  • To review the genes and pathways targeted by Myc.
  • To explore the role of Myc in stem cell biology.
  • To examine the involvement of Myc in cancer development.

Main Methods:

  • Expression profiling studies.
  • Genomic binding analyses.
  • Genetic analyses in mammals and Drosophila.

Main Results:

  • Myc targets a specific set of genes and pathways.
  • Myc plays a significant role in stem cell regulation.
  • Dysregulation of Myc is implicated in various cancers.

Conclusions:

  • Myc is a key regulator in cellular processes.
  • Understanding Myc's targets and roles is crucial for stem cell research and cancer therapy.
  • Further investigation into Myc's complex functions is warranted.