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Seizures are common in the acute setting of childhood stroke: a population-based study

Madeline A Chadehumbe1, Pooja Khatri, Jane C Khoury

  • 1Division of Child Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

Journal of Child Neurology
|October 17, 2008
PubMed

Insights

Seizures are common in children experiencing acute stroke, occurring in 58% of cases within 24 hours. This incidence is significantly higher compared to adults with acute stroke.

Area of Science:

  • Pediatric Neurology
  • Stroke Research
  • Epilepsy

Background:

  • Acute stroke in adults is associated with a 3.1% incidence of seizures within 24 hours.
  • The incidence and characteristics of acute seizures in pediatric stroke are less understood.
  • Understanding seizure occurrence in childhood stroke is crucial for timely diagnosis and management.

Purpose of the Study:

  • To determine the incidence of seizures within 24 hours of acute stroke in children.
  • To compare seizure incidence in pediatric stroke with that of adult stroke.
  • To analyze seizure occurrence by stroke subtype in children.

Main Methods:

  • Retrospective cohort study of pediatric stroke cases.
  • Data abstracted from two distinct 1-year periods: July 1993-June 1994 and January 1999-December 1999.
  • Identification and analysis of 31 pediatric stroke cases, including ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage.

Main Results:

  • Seizures occurred within 24 hours in 58% (18/31) of pediatric stroke cases.
  • No significant difference in seizure rates was observed across different stroke subtypes in children.
  • The relative risk of seizure in the acute stroke setting for children compared to adults is 18 (95% CI: 13-26).

Conclusions:

  • Seizures are highly prevalent in the acute setting of childhood stroke, occurring in 58% of cases.
  • Pediatric acute stroke carries a substantially higher risk of seizures compared to adult acute stroke.
  • Prompt recognition and management of seizures are essential in children presenting with acute stroke.

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