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Related Experiment Video

Updated: Jun 21, 2026

Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans

Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans

Published on: February 16, 2017

Centrosome misorientation reduces stem cell division during ageing.

Jun Cheng¹, Nezaket Türkel, Nahid Hemati

¹Department of Biomedical Engineering, Center for Ultrafast Optical Science, University of Michigan, Ann Arbor, Michigan 48109, USA.

|October 17, 2008

Summary

Stem cell aging in Drosophila is linked to misoriented centrosomes, disrupting asymmetric division and leading to reduced sperm production. Correcting orientation allows stem cells to re-enter the cell cycle.

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Area of Science:

Developmental Biology
Cell Biology
Aging Research

Background:

Adult stem cells maintain tissue homeostasis through asymmetric division.
Stem cell function decline contributes to tissue aging, but mechanisms are unclear.
Spermatogenesis decline in aged Drosophila males suggests stem cell dysfunction.

Purpose of the Study:

Investigate the mechanism linking stem cell aging to reduced spermatogenesis in Drosophila.
Determine the role of stem cell orientation and centrosome positioning in aging.

Main Methods:

Microscopy to observe centrosome orientation in Drosophila germline stem cells (GSCs).
Analysis of cell cycle progression in GSCs with varying centrosome orientation.
Tracking GSCs and spermatogonia to identify origins of misoriented cells.

Main Results:

Aging Drosophila GSCs accumulate with misoriented centrosomes.
Misoriented GSCs exhibit cell cycle arrest or delay.
Transient cell cycle arrest is resolved upon correction of centrosome orientation.
Some misoriented GSCs may arise from dedifferentiation of spermatogonia.

Conclusions:

Centrosome misorientation in aging GSCs disrupts asymmetric division and contributes to spermatogenesis decline.
Cell cycle arrest linked to misorientation acts as a safeguard for asymmetric division.
Maintaining correct stem cell orientation is crucial for tissue homeostasis during aging.