Related Experiment Video
Updated: Jun 28, 2026

Assaying the Ability of Diffusible Signaling Molecules to Reorient Embryonic Spinal Commissural Axons
Published on: March 8, 2010
Neuroregenerative strategies in the brain: emerging significance of bone morphogenetic protein 7 (BMP7)
Mahmud Bani-Yaghoub1, Roger G Tremblay, Abdellah Ajji
1Neurogenesis and Brain Repair Group, Neurobiology Program, Institute for Biological Sciences, National Research Council Canada, 1200 Montreal Rd., Bldg. M54, Ottawa, ON K1A 0R6, Canada. mahmud.bani@nrc.ca
Abstract:
Every year thousands of people suffer from brain injuries and stroke, and develop motor, sensory, and cognitive problems as a result of neuronal loss in the brain. Unfortunately, the damaged brain has a limited ability to enact repair and current modes of treatment are not sufficient to offset the damage. An extensive list of growth factors, neurotrophic factors, cytokines, and drugs has been explored as potential therapies. However, only a limited number of them may actually have the potential to effectively offset the brain injury or stroke-related problems. One of the treatments considered for future brain repair is bone morphogenetic protein 7 (BMP7), a factor currently used in patients to treat non-neurological diseases. The clinical application of BMP7 is based on its neuroprotective role in stroke animal models. This paper reviews the current approaches considered for brain repair and discusses the novel convergent strategies by which BMP7 potentially can induce neuroregeneration.

