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Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds

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Plasmodium telomeric sequences: structure, stability and quadruplex targeting by small compounds.

Anne De Cian¹, Philippe Grellier, Elisabeth Mouray

¹INSERM, U565, Paris Cedex 05, 75231, France.

Chembiochem : a European Journal of Chemical Biology

|October 17, 2008

Summary

This summary is machine-generated.

New antimalarial drug targets are needed due to Plasmodium falciparum resistance. Targeting parasite telomeres with G-quadruplex ligands shows promise, with ligands stabilizing Plasmodium telomeric G-quadruplex structures.

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Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes

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Published on: April 4, 2025

Area of Science:

Parasitology
Molecular Biology
Drug Discovery

Background:

Plasmodium falciparum exhibits increasing resistance to current antimalarial drugs.
Identifying novel therapeutic targets is crucial for malaria treatment.
Parasite telomeres represent a potential target due to their unique structure.

Purpose of the Study:

To investigate Plasmodium telomeres as a therapeutic target.
To explore the potential of G-quadruplex ligands against Plasmodium falciparum.

Main Methods:

Solution hybridization assays to detect telomeric 3' G-overhang.
UV spectroscopy to assess G-quadruplex formation.
FRET melting assays to evaluate ligand stabilization of G-quadruplexes.

Main Results:

Evidence of a telomeric 3' G-overhang in P. falciparum genomic DNA was found.
Stable G-quadruplex structures formed from Plasmodium telomeric motifs at physiological temperatures.
Various ligands stabilized Plasmodium telomeric G-quadruplexes, showing selectivity for quadruplex over duplex DNA.

Conclusions:

Plasmodium telomeric G-quadruplexes are a viable target for antimalarial drug development.
Ligands stabilizing these structures offer a potential therapeutic strategy.
Further research is needed to develop selective ligands distinguishing between human and Plasmodium telomeric quadruplexes.