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Drug discovery from nature: automated high-quality sample preparation
1Hans-Knöll-Institute for Natural Products Research, Beutenbergstrasse 11, Jena D-07745, Germany.
Journal of Automated Methods & Management in Chemistry
|October 18, 2008
Summary
Automated solid-phase extraction (SPE) enhances natural product drug discovery. This novel method generates high-quality samples from complex mixtures, making them competitive for high-throughput screening programs.
Area of Science:
- Natural Product Chemistry
- Drug Discovery
- Analytical Chemistry
Background:
- Secondary metabolites from natural sources are vital for drug discovery due to their structural diversity.
- Extracts from natural sources are complex mixtures, often requiring time-consuming manual preparation.
- The quality and quantity of natural samples are critical for high-throughput screening (HTS) success.
Purpose of the Study:
- To develop an automated sample preparation procedure for natural products.
- To make natural product samples competitive with synthetic compound libraries for drug discovery.
- To meet the requirements of high-throughput screening programs.
Main Methods:
- Development of a novel automated sample preparation procedure.
- Utilized a modified Zymark RapidTrace SPE workstation.
- Implemented solid-phase extraction (SPE) for sample fractionation.
Main Results:
- An easy-to-handle and effective fractionation method was developed.
- Generated high-quality samples from natural origins.
- Enabled integration of natural product samples into HTS programs.
Conclusions:
- Automated SPE significantly improves natural product sample preparation.
- The developed method addresses challenges in handling complex natural mixtures.
- This innovation enhances the utility of natural products in modern drug discovery pipelines.
