Automated Microdosing System for Integration With a Miniaturized High-pressure Reactor System

Area of Science:

• Chemical Engineering
• Automation Technology
• Materials Science

Background:

• Combinatorial synthesis requires precise and automated liquid handling.
• Existing dosing systems may have limitations in volume range, pressure, or temperature tolerance.
• Miniaturized reactor systems demand compact and efficient components.

Purpose of the Study:

• To introduce a novel automated dosing system for chemical liquids.
• To integrate this system into a miniaturized reactor for advanced synthesis applications.
• To detail the system's capabilities, features, and benefits.

Main Methods:

• Development of an automated dosing system by the Institute for Automation, University of Rostock.
• Integration of the dosing system into a miniaturized reactor.
• Testing the system's performance across a range of chemical liquids and operating conditions (up to 150 bar, 200°C).

Main Results:

• The system accurately dispenses chemical liquids within the 50 µL to 2.5 mL range.
• Successful integration with a high-pressure (150 bar) and high-temperature (200°C) reactor.
• Demonstrated capability to handle liquids with diverse physical properties.

Conclusions:

• The new automated dosing system offers a versatile and reliable solution for chemical liquid handling in combinatorial synthesis.
• Its integration with a miniaturized reactor enhances capabilities for high-throughput experimentation.
• The system presents significant potential benefits for researchers in chemical synthesis and materials science.