Analytical performance of the selective multianalyser Olympus AU 5200

Area of Science:

• Clinical chemistry
• Analytical instrumentation
• Laboratory diagnostics

Background:

• The Olympus AU5200 is a selective, automatic multianalyser.
• Evaluating new analytical instruments is crucial for laboratory efficiency and diagnostic accuracy.
• Previous models like the AU5000 provide a benchmark for performance comparison.

Purpose of the Study:

• To assess the analytical performance and practicability of the Olympus AU5200 analyser.
• To compare the AU5200's performance against the AU5000 and a Hitachi 747 analyser.
• To validate the AU5200 for routine clinical laboratory use according to ECCLS guidelines.

Main Methods:

• Tested 22 analytes on the Olympus AU5200, comparing results with the AU5000 and Hitachi 747.
• Evaluated imprecision (CV values), recovery, linearity, and carry-over.
• Assessed practicability including sample/reagent handling, software, and maintenance.

Main Results:

• Median CV values below 2% (intra-assay) and 3% (inter-assay) for most of the 22 analytes.
• Slightly improved precision and accuracy on AU5200 compared to AU5000 for most tests.
• Good recovery (95-105%) for 14 tests; acceptable deviations for others, with exceptions like albumin and certain enzymes.
• No sample carry-over detected; linearity within manufacturer specifications.
• Ion-selective electrode unit showed good throughput, precision, and stability.

Conclusions:

• The Olympus AU5200 exhibits high analytical performance, meeting or exceeding expectations for precision and accuracy.
• The analyser demonstrates excellent practicability, suitable for efficient clinical laboratory operations.
• The AU5200 is a reliable and effective automated analyser for a wide range of diagnostic tests.