Benzo[6,7]cyclohepta[1,2-b]pyran derivatives with platelet antiaggregating and other activities

¹Istituto di Farmacologia e Tossicologia, 1 Facoltà di Medicina e Chirurgia, Univerisità Federico II, Napoli, Italy.

Farmaco (Societa Chimica Italiana : 1989)

|March 1, 1991

Abstract:

The synthesis of some N,N-disubstituted 4-amino-6,7-dihydro-3-phenylbenzo[6,7]cyclohepta[1,2-b]pyran-2(5H) -ones by reaction of phenylchloroketene with a series of N,N-disubstituted 6-aminomethylene-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ones, followed by dehydrochlorination of the primary adducts with DBN, is described. Some compounds showed a platelet antiaggregating activity in vitro superior or comparable to that of acetylsalicylic acid, as well as a weak local anesthetic activity in mice and antiinflammatory activity in rats.

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Benzo[6,7]cyclohepta[1,2-b]pyran derivatives with platelet antiaggregating and other activities

Abstract:

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