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Automated serum chloride analysis using the Apple computer.

P J Taylor1, R A Bouska

  • 1Chemistry Department University of Wisconsin-La Crosse La Crosse Wisconsin 54601 USA.

The Journal of Automatic Chemistry
|January 1, 1988
PubMed
Summary

This study developed an automated chloride analysis system using an Apple computer for coulometric titration. The new method offers a rapid, accurate, and precise alternative to expensive, specialized equipment.

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Area of Science:

  • Analytical Chemistry
  • Electrochemistry
  • Instrumentation

Background:

  • Coulometric titration is a standard method for chloride analysis.
  • Existing equipment is specialized and costly, limiting accessibility.
  • There is a need for a more automated and cost-effective solution.

Purpose of the Study:

  • To develop hardware and software for automated coulometric titration of chloride using an Apple computer.
  • To create a system that controls, automates, and reports chloride analysis results.
  • To provide an accessible and precise method for chloride determination.

Main Methods:

  • Utilized an Apple computer to control current flow in a circuit with silver and platinum electrodes.
  • Implemented electrochemical reactions for silver ion generation and chloride precipitation (Ag+ + Cl- -> AgCl(s)).
  • Employed a silver microelectrode system to detect titration endpoint via current change, converted to voltage for computer processing.

Main Results:

  • The developed system successfully automated coulometric titration and data reporting.
  • Analysis of standards and reference sera demonstrated rapid, accurate, and precise chloride measurements.
  • The apparatus functions effectively as a teaching tool for chemistry and medical students.

Conclusions:

  • The Apple computer-controlled coulometric titration system provides an accurate, precise, and automated method for chloride analysis.
  • This innovation reduces reliance on expensive, specialized equipment.
  • The system has potential applications in both routine analysis and as an educational aid.