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Related Concept Videos

Cytoskeletal Accessory Proteins01:13

Cytoskeletal Accessory Proteins

The cytoskeleton is an essential cell component that plays several structural and functional roles. However, the filaments that make up the cytoskeleton cannot function independently and depend on the accessory or ancillary proteins to effectively carry out their function. Accessory proteins associate with cytoskeletal filaments and their monomers, aiding filament formation and function. They also help in the cross-communication among cytoskeletal filaments. Cytoskeletal accessory proteins are...
Pinching-off of Coated Vesicles01:32

Pinching-off of Coated Vesicles

Vesicle budding is orchestrated by distinct cytosolic proteins such as adaptor proteins, coat proteins, and GTPases. To initiate vesicle budding, membrane-bending proteins containing crescent-shaped BAR domains bind to the lipid heads in the bilayer and distort the membrane to form a protein-coated vesicle bud. Adaptors proteins such as AP2 for clathrin-coated vesicles can nucleate on the deformed membrane. Finally, coat proteins such as clathrin or COPI and COPII assemble into a coat forming...
Condensins02:15

Condensins

Condensins are large protein complexes that use ATP to fuel the assembly of chromosomes during mitosis. They transform the tangled, shapeless mass of post-interphase DNA into individualized chromosomes by compacting, organizing, and segregating chromosomal DNA.
The plant and animal cells contain two types of condensin complexes—condensin I and condensin II. Both complexes have five subunits: two SMC (Structural Maintenance of Chromosomes) subunits, a kleisin subunit, and two HEAT-repeat...
Condensins02:15

Condensins

Condensins are large protein complexes that use ATP to fuel the assembly of chromosomes during mitosis. They transform the tangled, shapeless mass of post-interphase DNA into individualized chromosomes by compacting, organizing, and segregating chromosomal DNA.
The plant and animal cells contain two types of condensin complexes—condensin I and condensin II. Both complexes have five subunits: two SMC (Structural Maintenance of Chromosomes) subunits, a kleisin subunit, and two HEAT-repeat...
Catenins01:23

Catenins

Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction complexes. All catenins, except α-catenin, contain a characteristic protein sequence called the armadillo repeat and are therefore also called armadillo proteins.
Catenins in Cell Junctions
Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the adherens...
Selectins01:25

Selectins

Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...

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Related Experiment Video

Updated: Jun 28, 2026

Investigating the Function of Coronin A in the Early Starvation Response of Dictyostelium discoideum by Aggregation Assays
07:48

Investigating the Function of Coronin A in the Early Starvation Response of Dictyostelium discoideum by Aggregation Assays

Published on: June 18, 2016

Invertebrate coronins.

Maria C Shina1, Angelika A Noegel

  • 1Center for Biochemistry, Medical Faculty, University of Cologne, Joseph-Stelzmann-Strasse 52, Cologne, Germany.

Sub-Cellular Biochemistry
|October 18, 2008
PubMed
Summary

Coronins are conserved proteins crucial for actin-dependent processes. Genetic studies in fruit flies and amoebas highlight their regulatory roles in cellular functions.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Genetics

Background:

  • Coronins are a family of highly conserved proteins found across diverse species.
  • Despite conservation, the detailed functions of coronins remain largely unelucidated.
  • This study focuses on coronin-like proteins in model organisms: Drosophila melanogaster, Caenorhabditis elegans, and Dictyostelium discoideum.

Purpose of the Study:

  • To introduce coronin-like proteins from key model organisms.
  • To investigate the functional significance of coronins in actin-dependent processes.
  • To provide genetic insights into coronin regulation.

Main Methods:

  • Comparative analysis of coronin-like protein families.
  • Genetic analysis in Drosophila melanogaster.

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The C. elegans Intestine As a Model for Intercellular Lumen Morphogenesis and In Vivo Polarized Membrane Biogenesis at the Single-cell Level: Labeling by Antibody Staining, RNAi Loss-of-function Analysis and Imaging
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The C. elegans Intestine As a Model for Intercellular Lumen Morphogenesis and In Vivo Polarized Membrane Biogenesis at the Single-cell Level: Labeling by Antibody Staining, RNAi Loss-of-function Analysis and Imaging

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Last Updated: Jun 28, 2026

Investigating the Function of Coronin A in the Early Starvation Response of Dictyostelium discoideum by Aggregation Assays
07:48

Investigating the Function of Coronin A in the Early Starvation Response of Dictyostelium discoideum by Aggregation Assays

Published on: June 18, 2016

In Situ Hybridization Techniques for Paraffin-Embedded Adult Coral Samples
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In Situ Hybridization Techniques for Paraffin-Embedded Adult Coral Samples

Published on: August 31, 2018

The C. elegans Intestine As a Model for Intercellular Lumen Morphogenesis and In Vivo Polarized Membrane Biogenesis at the Single-cell Level: Labeling by Antibody Staining, RNAi Loss-of-function Analysis and Imaging
12:15

The C. elegans Intestine As a Model for Intercellular Lumen Morphogenesis and In Vivo Polarized Membrane Biogenesis at the Single-cell Level: Labeling by Antibody Staining, RNAi Loss-of-function Analysis and Imaging

Published on: October 3, 2017

  • Genetic analysis in Dictyostelium discoideum.

    • Main Results:

    • Coronins are present in Drosophila melanogaster, Caenorhabditis elegans, and Dictyostelium discoideum.
    • Genetic data indicates coronins are vital regulators of actin-dependent cellular activities.
    • These findings underscore the conserved importance of coronins in biological systems.

    Conclusions:

    • Coronins play essential roles in regulating actin-dependent processes across different species.
    • Genetic data from model organisms confirms the functional significance of coronins.
    • Further research into coronin function is warranted to fully understand their molecular mechanisms.