Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...

Myasthenia Gravis: Overview and Treatment

Myasthenia Gravis: Overview and Treatment

Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which leads...

Poliomyelitis

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...

Myasthenia Gravis ll: Pathophysiology

Myasthenia Gravis ll: Pathophysiology

The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...

Nephrotic Syndrome II : Assessment and Medical Management

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...

Nephrons

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma happens...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Gender Differences in the Trajectory and Predictors of Unmet Needs Among Young Stroke Survivors: A Longitudinal Secondary Analysis.

The Journal of cardiovascular nursing·2026

Same author

Longitudinal Study on Unmet Needs in Young Stroke Survivors: Predictive Factors and Consequences.

Journal of clinical nursing·2025

Same author

The Care Needs, Preferences, and Coping Strategies of Young Stroke Survivors: A Qualitative Study.

The Journal of cardiovascular nursing·2025

Same author

Evaluating the combination of in-person and electronic social networking services for family caregivers of stroke survivors: A quasi-experimental analysis.

Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing·2024

Same author

Development and validation of the Unmet Needs Questionnaire for young stroke survivors.

Clinical rehabilitation·2024

Same author

Protective Effect of Alpha-Linolenic Acid on Human Oral Squamous Cell Carcinoma Metastasis and Apoptotic Cell Death.

Nutrients·2023

Search research articles

Related Experiment Video

Updated: Jun 28, 2026

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation

Published on: August 19, 2020

Paraneoplastic polymyositis associated with crescentic glomerulonephritis.

Kuan-Chi Chiu¹, Tsung-Chang Tsai, Wei-Tung Lin

¹Department of Radiology, Tinan Municipal Hospital, Tainan City, Taiwan, ROC.

|October 18, 2008

Summary

Polymyositis (PM) with crescentic glomerulonephritis and lung cancer resolved after lung cancer surgery. This rare case highlights the importance of evaluating malignancy in PM patients with kidney involvement.

Related Experiment Videos

Last Updated: Jun 28, 2026

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation

Published on: August 19, 2020

Area of Science:

Nephrology
Rheumatology
Oncology

Background:

Polymyositis (PM) is an idiopathic inflammatory myopathy.
Renal involvement in PM is uncommon, with crescentic glomerulonephritis being particularly rare.
Malignancy is associated with an increased risk in PM patients.

Observation:

A female patient presented with concurrent polymyositis, lung adenocarcinoma, and nephrotic syndrome.
Renal biopsy confirmed crescentic glomerulonephritis.
Symptoms of PM and glomerulonephritis resolved following surgical resection of the lung cancer.

Findings:

This case demonstrates a rare association between polymyositis, crescentic glomerulonephritis, and lung adenocarcinoma.
Successful treatment of the underlying malignancy led to the remission of PM-associated renal disease.
The findings suggest a potential paraneoplastic link between lung cancer and PM with glomerulonephritis.

Implications:

Early and thorough evaluation for underlying malignancy is crucial in polymyositis patients presenting with renal abnormalities.
Management of the underlying malignancy may lead to significant improvement in associated autoimmune conditions like crescentic glomerulonephritis.
This case underscores the importance of a multidisciplinary approach in managing complex cases involving rheumatologic, oncologic, and nephrologic conditions.