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RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
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RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma

Published on: March 11, 2014

Low grade peritoneal mucinous carcinomatosis associated with human papilloma virus infection: case report

Zoran Gatalica1, Jason M Foster, Brian W Loggie

  • 1Department of Pathology, Creighton University Medical Center, 601 N 30th St., Omaha, NE 68131, USA. zorangatalica@creighton.edu

Croatian Medical Journal
|October 18, 2008
PubMed

Insights

Pseudomyxoma peritonei, typically from the appendix, was linked to cervical cancer in a rare case. This study highlights a novel association between human papillomavirus (HPV) and this rare malignancy.

Area of Science:

  • Gynecologic Oncology
  • Oncology
  • Pathology

Background:

  • Pseudomyxoma peritonei (PMP) is a rare condition characterized by mucinous ascites and peritoneal tumor spread, most commonly originating from appendiceal neoplasms.
  • The etiology of PMP is typically linked to mucinous adenocarcinomas, predominantly of appendiceal origin.

Observation:

  • This report details a unique case of PMP in a 60-year-old woman presenting as low-grade mucinous peritoneal carcinomatosis eight years post-hysterectomy for cervical adenocarcinoma.
  • Extensive investigation excluded other primary mucinous tumors, and the peritoneal carcinomatosis was confirmed to be positive for high-risk human papillomavirus (HPV), exhibiting both integrated and episomal patterns.

Findings:

  • This case represents the first documented instance of pseudomyxoma peritonei associated with a human papillomavirus (HPV)-positive cervical adenocarcinoma.
  • The findings challenge the established understanding of PMP origins and suggest a potential role for HPV in the development of PMP in specific gynecologic malignancies.

Implications:

  • This discovery broadens the spectrum of known causes for pseudomyxoma peritonei.
  • It underscores the importance of considering HPV-driven gynecologic cancers in the differential diagnosis of PMP, even in the absence of a clear appendiceal primary.
  • Further research is warranted to explore the oncogenic pathways linking HPV to PMP development.

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