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Early markers of allergic disease in a primary prevention study using probiotics: 2.5-year follow-up phase

S L Prescott1, J Wiltschut, A Taylor

  • 1School of Paediatrics and Child Health, University of Western Australia, Perth, WA, Australia.

Allergy
|October 18, 2008
PubMed

Insights

The Lactobacillus acidophilus probiotic strain LAFTI L10 did not impact allergy outcomes in children. Early immune differences, including regulatory T-cell markers, were observed in allergic children.

Area of Science:

  • Immunology
  • Allergy Research
  • Microbiome Studies

Background:

  • Previous research indicated a potential increased risk of allergen sensitization at one year of age with Lactobacillus acidophilus probiotic strain LAFTI L10 supplementation during infancy.
  • This study aimed to evaluate the long-term effects of this probiotic on allergic outcomes.

Purpose of the Study:

  • To assess the impact of Lactobacillus acidophilus probiotic strain LAFTI L10 on allergic disease development and allergen sensitization up to 2.5 years of age.
  • To investigate the relationship between early immune function at 6 months and subsequent allergic outcomes.

Main Methods:

  • A cohort of 153 children from an initial prevention trial were followed up to 2.5 years of age.
  • Clinical outcomes (dermatitis, allergic disease, sensitization) and immune markers (T-cells, cytokine responses) were assessed in relation to probiotic supplementation and early immune function.

Main Results:

  • Probiotic supplementation did not reduce the incidence of dermatitis or other allergic diseases by 2.5 years.
  • Inhalant sensitization at 2.5 years was associated with higher regulatory T-cell populations and FOXP3 levels at 6 months.
  • Children with dermatitis exhibited altered innate immune responses and lower toll-like receptor 4 responses at 6 months.

Conclusions:

  • The Lactobacillus acidophilus LAFTI L10 probiotic strain showed no significant long-term benefit for allergy outcomes.
  • Early differences in immune function, including regulatory T-cell markers and innate immunity, were identified in children who developed allergies.
Abstract

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