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Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Sputum Studies II: Culture and Sensitivity01:20

Sputum Studies II: Culture and Sensitivity

Description
Sputum culture and sensitivity is a medical procedure used to diagnose bacterial infections in the respiratory tract and select the most appropriate antibiotics for treatment. This process involves analyzing sputum samples of thick and opaque secretions produced in the lungs and airways. These samples are collected from patients and then sent to the laboratory for analysis.
The test can identify various pathogens responsible for respiratory infections, including Streptococcus,...

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Related Experiment Video

Updated: Jun 28, 2026

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
06:34

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

Understanding patient sensitization profiles in complex pollen areas: a molecular epidemiological study.

D Barber1, F de la Torre, F Feo

  • 1Departamento de I+D, ALK-Abelló, Madrid, Spain.

Allergy
|October 18, 2008
PubMed
Summary

Component-resolved diagnosis reveals that high pollen exposure creates distinct sensitization profiles, with minor allergens like Ole e 7 and Ole e 9 indicating more severe olive allergies. Profilin sensitization is linked to severe grass allergies.

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Flow Cytometric Analysis of Particle-bound Bet v 1 Allergen in PM10
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Last Updated: Jun 28, 2026

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
06:34

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

Flow Cytometric Analysis of Particle-bound Bet v 1 Allergen in PM10
10:42

Flow Cytometric Analysis of Particle-bound Bet v 1 Allergen in PM10

Published on: November 19, 2016

Area of Science:

  • Allergen immunotherapy
  • Clinical immunology
  • Environmental allergy

Background:

  • Allergy diagnosis is complex in patients with multiple pollen exposures.
  • Misdiagnosis can lead to unsuccessful specific immunotherapy.
  • Understanding individual allergen sensitization is crucial for effective treatment.

Purpose of the Study:

  • To investigate individual allergen sensitization profiles in pollen-allergic patients.
  • To assess the impact of minor olive allergens on allergic disease severity.
  • To explore associations between pan-allergen and minor allergen sensitizations.

Main Methods:

  • Screened 891 patients for sensitization to 13 purified allergens.
  • Included major, minor, and pan-allergens relevant to the region.
  • Utilized high-capacity technology (ADVIA-Centaur) for specific IgE testing.

Main Results:

  • Olive allergy (Ole e 1) was the most prevalent pollinosis.
  • Minor olive allergens (Ole e 7, Ole e 9) correlated with severe allergic illness.
  • Profilin sensitization was linked to grass allergy; Pru p 3 sensitization was notable.

Conclusions:

  • Component-resolved diagnosis offers new insights into allergen exposure and sensitization.
  • High allergen exposure can lead to differential sensitization profiles associated with severe conditions.
  • Profilin sensitization predicts more severe grass pollen allergy.