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[Wilms' tumor. Our clinical experience]
Insights
This study on childhood Wilms' tumour found that survival rates decrease with advanced clinical stage. Younger children (under 2 years) had better survival outcomes than older children.
Area of Science:
- Pediatric Oncology
- Clinical Research
- Cancer Survival Rates
Context:
- Evaluation of treatment outcomes for pediatric Wilms' tumour.
- Analysis of patient data from 1967-1975.
- Involves 11 males and 12 females.
Purpose:
- To assess the survival rates of children diagnosed with Wilms' tumour.
- To investigate the influence of clinical stage, age at diagnosis, and sex on survival.
- To provide insights into prognostic factors for pediatric kidney cancer.
Summary:
- Survival rates for Wilms' tumour decrease progressively with higher clinical stages (Stage I: 100% at 36 months).
- Younger patients (under 2 years) showed significantly better 2-year survival (50%) compared to older patients (>2 years, 24%).
- Patient sex did not appear to be a significant prognostic factor.
Impact:
- Highlights the critical role of clinical stage and age in Wilms' tumour prognosis.
- Informs treatment strategies and patient counseling for pediatric kidney cancer.
- Provides historical data for comparison with contemporary treatment protocols.
Abstract:
The survival of children with Wilms' tumour is evaluated in 11 males and 12 females treated between 1967 and 1975 in the light of the clinical stage, age at diagnosis, and sex. The subjects were aged from 4 months to 6 years. Six were in stage I, 4 in stage II, 4 in stage III, 7 in stage IV, and 2 in stage V. Survival in stage I was 100% at 36 months and gradually decreased with the stage. Patients aged less than 2 years presented a survival of 50% two years after diagnosis, compared to 24% in those over 2 years old. Sex appears to be irrelevant to prognosis.