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[Stability at different pH of polyene antibiotics derived from partricin]
G Mozzi1, L Mirabelli, V R Nipoti
1Laboratori di Ricerca della SPA, Società Prodotti Antibiotici S.p.A., Milano.
Bollettino Chimico Farmaceutico
|March 1, 1991
Abstract:
The degradation of a new semisynthetic polyene antibiotic partricin A dimethylamino ethylamide diaspartate (SPA-S-717) at 37 degrees C in water at different pH is studied. It is found to be sensitive to acidic pH and much less sensitive near neutrality. Then a linear relation between pH and logarithm of reaction rate constant is detected. This fact therefore can give some directions as regards the drug somministration in view of pharmacological and clinical trials.