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Updated: Jun 28, 2026

Assessing Cellular Target Engagement by SHP2 (PTPN11) Phosphatase Inhibitors
Published on: July 17, 2020
Recent advances in the genetic analysis of PTEN and PI3K innate immune properties
Philipp Günzl1, Gernot Schabbauer
1Institute for Vascular Biology and Thrombosis Research, Center for Biomolecular Medicine and Pharmacology, Medical University Vienna, A-1090 Vienna, Austria.
Abstract:
The role of the PI3-kinase pathway and its antagonist PTEN in the regulation of innate immune responses has only recently attracted the attention of the scientific community. The PI3K/PTEN signaling axis is most renowned for its critical involvement in the malignant transformation of cells leading to tumorigenesis. PI3K function in the regulation of innate immunity, either pro-inflammatory or anti-inflammatory, is still a controversial issue. Undoubtedly, PI3K serves as an essential pro-inflammatory signaling molecule to activate leukocytes, initiate migration and facilitate phagocytosis. Nevertheless, it is less clear how PI3K and PTEN modulate the amplitude of immune responses. Here, we review recent advances on the immune biology by means of reverse genetics analyzing the role of the PI3K/PTEN signaling cascade in innate immunity.
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