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Related Experiment Video

Updated: Jun 28, 2026

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock

Published on: August 16, 2021

Differences in pulsatile and non-pulsatile mechanical circulatory support in long-term use.

Thorsten Drews¹, Michael Jurmann, Dandel Michael

¹Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum, Berlin, Germany. drews@dhzb.de

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation

|October 18, 2008

Summary

Non-pulsatile left ventricular assist devices (LVADs) show promise for long-term mechanical circulatory support. While pulsatile LVADs offer better initial left ventricular unloading, non-pulsatile devices demonstrate advantages in durability and patient quality of life for extended use.

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Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart

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Last Updated: Jun 28, 2026

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock

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Published on: August 16, 2021

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart

Published on: May 11, 2018

Area of Science:

Cardiology
Biomedical Engineering
Medical Devices

Background:

Left ventricular assist devices (LVADs) are crucial for managing advanced heart failure.
Interest is growing in non-pulsatile LVAD systems for long-term mechanical circulatory support (MCS).
This study compares the outcomes of pulsatile and non-pulsatile LVADs in patients requiring MCS for over one year.

Purpose of the Study:

To evaluate and compare the long-term efficacy and safety of pulsatile versus non-pulsatile LVADs.
To assess patient outcomes, device performance, and complication rates for both types of LVADs.
To determine the preferred LVAD type for extended use based on clinical data and quality of life.

Main Methods:

A cohort study involving 48 patients receiving either pulsatile (Group A, n=24) or non-pulsatile (Group B, n=24) LVADs.
Patients were followed for a minimum of one year of MCS.
Data collected included support duration, patient mobility, VAD-related complications, echocardiographic parameters, and clinical outcomes.

Main Results:

Mean support duration was longer in Group A (862 days) than Group B (631 days).
A high percentage of patients in both groups (80% Group A, 88% Group B) were discharged home for over a year.
Echocardiography indicated superior left ventricular unloading in Group A, though complication rates were similar between groups.

Conclusions:

While pulsatile LVADs may offer better initial left ventricular unloading, non-pulsatile devices are preferred for long-term use due to sufficient unloading, durability, and improved quality of life.
Both pulsatile and non-pulsatile LVAD systems can provide good quality of life and acceptable complication rates for extended periods.
Further investigation with right ventricle catheterization is needed to fully confirm echocardiographic findings on LV unloading differences.