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Updated: Jun 28, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
Published on: November 3, 2011
SDR: a database of predicted specificity-determining residues in proteins
Jason E Donald1, Eugene I Shakhnovich
1Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA. jdon@mail.med.upenn.edu
Abstract:
The specificity-determining residue database (SDR database) presents residue positions where mutations are predicted to have changed protein function in large protein families. Because the database pre-calculates predictions on existing protein sequence alignments, users can quickly find the predictions by selecting the appropriate protein family or searching by protein sequence. Predictions can be used to guide mutagenesis or to gain a better understanding of specificity changes in a protein family. The database is available on the web at http://paradox.harvard.edu/sdr.
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