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Published on: October 20, 2019
Mannose-binding lectin-2 genotypes and recurrent late pregnancy losses
Ole B Christiansen1, Henriette S Nielsen, Marie Lund
1Fertility Clinic 4071, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. obc@pregnancyloss.dk
Human Reproduction (Oxford, England)
|October 18, 2008
Summary
Mannose-binding lectin (MBL) deficiency is linked to recurrent late pregnancy losses (RLPL), particularly in cases with no clear cause. This suggests inflammation may contribute to this condition.
Area of Science:
- Immunology
- Reproductive Medicine
- Genetics
Background:
- Low mannose-binding lectin (MBL) levels are linked to infections and inflammatory conditions.
- MBL deficiency has been associated with recurrent early miscarriages.
- Recurrent late pregnancy losses (RLPL) in the second trimester are rare, devastating, and often maternal in origin.
Purpose of the Study:
- To investigate the association between MBL deficiency and recurrent late pregnancy losses (RLPL).
- To determine if MBL2 gene polymorphisms correlate with RLPL in different patient subgroups.
Main Methods:
- Studied 75 patients with at least two late pregnancy losses (14-30 weeks) and 104 controls.
- Analyzed MBL2 gene polymorphisms associated with MBL plasma levels.
- Classified patients into groups: cervical insufficiency, lupus anticoagulant (LAC) positive, and idiopathic RLPL.
Main Results:
- 26.7% of RLPL patients had MBL-deficient genotypes vs. 12.5% in controls (OR 2.55, P < 0.02).
- No significant increase in MBL deficiency was found in cervical insufficiency or LAC groups.
- 36.8% of idiopathic RLPL patients had low-producing MBL2 genotypes vs. controls (OR 4.08, P = 0.001).
Conclusions:
- MBL deficiency is strongly associated with idiopathic recurrent late pregnancy losses.
- This association suggests a potential role for excessive inflammatory disturbances in RLPL etiology.
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