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Updated: Jun 28, 2026

Promotion of Survival and Differentiation of Neural Stem Cells with Fibrin and Growth Factor Cocktails after Severe Spinal Cord Injury
Published on: July 27, 2014
Endogenous neural progenitor cells as therapeutic target after spinal cord injury
Franz-Josef Obermair1, Aileen Schröter, Michaela Thallmair
1Brain Research Institute, University of Zurich, and Department of Neuromorphology, ETH Zurich, Zurich, Switzerland.
Abstract:
Growing knowledge about the role of neural progenitor cells supports the hope that stem cell-based therapeutic approaches aimed at restoring function in the lesioned central nervous system can be established. Possible therapies for promoting recovery after spinal cord injury include stimulating the formation of neurons and glial cells by endogenous progenitor cells. This article reviews the current knowledge about the nature of adult progenitor cells in the intact and injured spinal cord and summarizes possibilities and limitations of cellular replacement strategies based on manipulations of endogenous spinal cord progenitor cells and their environment.
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