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A multiplex PCR assay for simultaneous detection of Corynebacterium diphtheriae and differentiation between

Fabricia P Pimenta1, Raphael Hirata1, Ana C P Rosa1

  • 1Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.

Journal of Medical Microbiology
|October 18, 2008
PubMed
Abstract

No abstract available in PubMed .

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Diphtheria01:28

Diphtheria

Diphtheria is an acute, toxin-mediated infectious disease that primarily affects the upper respiratory tract. It is caused by Corynebacterium diphtheriae, a Gram-positive, pleomorphic rod that lacks spore-forming capability and exhibits a characteristic club-shaped morphology under microscopic examination. While C. diphtheriae can asymptomatically colonize mucosal surfaces, clinical disease manifests only when the bacterial strain is lysogenized by a specific β-corynephage. This phage...