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Updated: Jun 28, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
Factor v leiden mutation in reocclusion after intra-arterial thrombolysis
Abraham Kuruvilla1, Gregory M Norris, Sunil Manjila
1Department of Neurology, WSU/DMC Comprehensive Stroke Program, Wayne State University School of Medicine, Detroit, Michigan 48201, USA. akuruvilla@doctor4u.com
Background And Purpose:
Reocclusion of intracranial arteries after successful recanalization is associated with poor clinical outcome. The role of Factor V Leiden mutation in intracranial arterial thrombosis/rethrombosis is unclear.
Summary Of Report:
We report the case of a patient who developed recurrent reocclusions of the middle cerebral artery after intra-arterial thrombolysis for acute ischemic stroke. The patient subsequently underwent transcatheter clot retrieval followed by successful stent-supported angioplasty of the occluded segment. He underwent a detailed workup for thrombophilia. The patient was detected to be heterozygous for Factor V Leiden mutation without any other cause for thrombophilia.
Conclusions:
Factor V Leiden mutation could be a contributing etiology for reocclusion after endovascular interventions in stroke. Systematic studies looking for thrombophilic mutations in patients with arterial reocclusion might be warranted.
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