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Updated: Jun 28, 2026
03:08
Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization
Published on: October 3, 2025
Genomic-scale prioritization of drug targets: the TDR Targets database
Fernán Agüero1, Bissan Al-Lazikani, Martin Aslett
1Instituto de Investigaciones Biotecnológicas, Universidad Nacional de General San Martín, San Martín 1650, Buenos Aires, Argentina. fernan@unsam.edu.ar
Nature Reviews. Drug Discovery
|October 18, 2008
Summary
Genomic data for tropical disease pathogens is growing, enabling new drug discovery. The TDR Targets database integrates this data to help identify and prioritize drug targets for these diseases.
Area of Science:
- Genomics and Bioinformatics
- Drug Discovery
- Tropical Medicine
Background:
- Genomic data for tropical disease pathogens is increasingly available.
- Effective data integration and interrogation are crucial for drug discovery.
- Existing data resources may lack comprehensive integration for target identification.
Purpose of the Study:
- To discuss the development of the TDR Targets database.
- To create a resource integrating diverse data types for tropical disease pathogens.
- To facilitate the identification and prioritization of drug targets.
Main Methods:
- Development of the TDR Targets database (http://tdrtargets.org).
- Inclusion of genetic, biochemical, and pharmacological data.
- Integration of computationally predicted druggability and compound desirability.
Main Results:
- The TDR Targets database provides a centralized repository of pathogen data.
- It enables the integration and weighting of diverse information.
- Facilitates computational prediction of target druggability.
Conclusions:
- The TDR Targets database supports efficient drug target identification for tropical diseases.
- Integrated data enhances the prioritization of potential drug candidates.
- This resource is valuable for accelerating drug discovery efforts.
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