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Updated: Jun 28, 2026

Isolation and Quantification of Botulinum Neurotoxin From Complex Matrices Using the BoTest Matrix Assays
Published on: March 3, 2014
[Long-term safety of therapeutic botulinum toxin A]
1Neurologische Klinik mit klinischer Neurophysiologie, Klinikum Augsburg. markus.naumann@klinikum-augsburg.de
Abstract:
For more than 20 years, therapeutic botulinum toxin A has been applied with success. With this long experience, the substance can viewed as safe and low in side effects. This was confirmed by a recent meta-analysis of placebo-controlled clinical studies. The side effects documented were light to moderate, temporary, and local. In respect to the frequently needed long-term therapy, it is necessary that botulinum toxin A be safe and cause no disturbance. The development of neutralizing antibodies to botulinum toxin A is very rare and no longer has an appreciable effect on its clinical application.
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