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[Current therapy for polymyositis and dermatomyositis]
1Service de Médecine Interne I, Hôpital Salpétrière, 47, boulevard de l'Hôpital, 75651 Paris cedex 13, France. patrick.cherin@psl.ap-hop-paris.fr
Summary
Polymyositis, dermatomyositis, and inclusion body myositis are severe inflammatory muscle diseases. Prognosis depends on diagnosis, antibodies, and treatment timing, with corticosteroids as primary therapy.
Area of Science:
- Rheumatology
- Neurology
- Immunology
Context:
- Polymyositis (PM), dermatomyositis (DM), and sporadic inclusion body myositis (s-IBM) are serious inflammatory myopathies.
- These conditions can lead to life-threatening complications and have unknown etiologies.
Purpose:
- To outline factors influencing prognosis and treatment response in inflammatory myopathies.
- To review current and potential therapeutic strategies for PM, DM, and s-IBM.
Summary:
- Prognosis and treatment efficacy in PM, DM, and s-IBM are influenced by diagnostic group, myositis-specific antibodies, extraskeletal involvement, and treatment delay.
- Corticosteroids are the primary treatment for PM and DM; immunosuppressants or IVIg are used for refractory cases.
- Intravenous immunoglobulin (IVIg) is recommended for severe myositis with dysphagia.
- Emerging therapies like anti-TNF and anti-CD20 agents warrant further investigation.
Impact:
- Provides a comprehensive overview of prognostic indicators and therapeutic options for inflammatory myopathies.
- Highlights the importance of personalized medicine based on patient-specific factors.
- Suggests future research directions for novel treatments in rare muscle diseases.
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