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[The importance of homocysteinemia measurement in chronic renal failure]

Velibor Cabarkapa1, Zoran Stosić, Radmila Zeravica

  • 1Institut za laboratorijsku medicinu, Klinicki centar Vojvodine, Novi Sad. veliborcabarkapa@nspoint.net

Medicinski Pregled
|October 22, 2008
PubMed

Insights

High homocysteine levels are common in chronic kidney disease patients, particularly those with reduced kidney function. This condition, hyperhomocysteinemia, is a significant risk factor for cardiovascular disease in this population.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Clinical Chemistry

Context:

  • Hyperhomocysteinemia is a known independent risk factor for premature cardiovascular disease.
  • Chronic renal failure (CRF) is associated with various metabolic disturbances.
  • The prevalence of hyperhomocysteinemia in different stages of CRF requires further investigation.

Purpose:

  • To determine the prevalence of elevated plasma homocysteine levels in patients with varying stages of chronic renal failure.
  • To assess the relationship between homocysteine levels and the severity of renal impairment.

Summary:

  • A study involving 105 subjects (73 CRF patients, 31 on hemodialysis, and 32 controls) examined plasma homocysteine levels.
  • Results indicated a high prevalence of hyperhomocysteinemia in CRF patients.
  • Elevated homocysteine levels were particularly noted when glomerular filtration rate was reduced by over 50%.

Impact:

  • Hyperhomocysteinemia is a significant risk factor for cardiovascular diseases in patients with chronic renal failure.
  • Findings highlight the importance of monitoring homocysteine levels in CRF patients for cardiovascular risk assessment.
  • This research underscores the link between renal function decline and homocysteine-related cardiovascular risks.
Abstract

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