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Updated: Jun 28, 2026

Study of Short Peptide Adsorption on Solution Dispersed Inorganic Nanoparticles Using Depletion Method
Published on: April 11, 2020
Peptide-based SAMs that resist the adsorption of proteins
Rolf Chelmowski1, Stephan David Köster, Andreas Kerstan
1Physikalische Chemie 1 and Anorganische Chemie I, Ruhr-Universität Bochum, 44780 Bochum, Germany.
Abstract:
In this paper we present a modular approach for the fabrication of surfaces to characterize protein-protein interactions. The approach is based on azido peptides with an optimized sequence which are then thiol-functionalized using an alkynyl thiol and "click" chemistry. From these peptide thiols we fabricated SAMs on gold to evaluate the protein resistance, using surface plasmon resonance spectroscopy, toward streptavidin, bovin serum albumin (BSA), and fibronectin.
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