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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

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Related Experiment Video

Updated: Jun 28, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
08:01

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

Notch signaling in pediatric malignancies.

Patrick A Zweidler-McKay1

  • 1The Children's Cancer Hospital, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 853, Houston, TX 77030, USA. PZweidler@MDAnderson.org

Current Oncology Reports
|October 22, 2008
PubMed
Summary

Notch signaling impacts pediatric cancers, influencing tumor growth, spread, and stem cells. Understanding its varied roles is key to developing targeted therapies for these diseases.

Area of Science:

  • Oncology
  • Developmental Biology
  • Molecular Signaling

Background:

  • Notch signaling is vital for development and linked to developmental disorders.
  • Pediatric malignancies often stem from disrupted developmental processes.
  • The Notch pathway's role in pediatric cancers is increasingly recognized.

Purpose of the Study:

  • To explore the multifaceted roles of Notch signaling in various pediatric cancers.
  • To identify how Notch pathway dysregulation contributes to cancer development and progression.
  • To lay the groundwork for Notch-targeted therapeutic strategies in pediatric oncology.

Main Methods:

  • Review of existing literature on Notch signaling in pediatric malignancies.
  • Analysis of specific pediatric cancer types where Notch pathway alterations are implicated.

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Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
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Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

Related Experiment Videos

Last Updated: Jun 28, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
08:01

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

  • Correlation of Notch pathway activity with cancer hallmarks like differentiation, metastasis, and angiogenesis.

    • Main Results:

    • Notch signaling exhibits diverse functions across different pediatric cancers.
    • Activating Notch1 mutations are prevalent in T-cell acute lymphoblastic leukemia (ALL).
    • Notch/HES1 signaling acts as a tumor suppressor in precursor B-cell ALL but promotes osteosarcoma metastasis.

    Conclusions:

    • Notch signaling plays complex, context-dependent roles in pediatric cancers.
    • Its involvement spans differentiation, metastasis, cancer stem cells, and angiogenesis.
    • Further research into Notch signaling in specific pediatric cancers is crucial for therapeutic development.