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Does atopy affect the radiological extent of pulmonary tuberculosis?
1Division of Allergy. Gulhane Military Medical Academy Haydarpasa Teaching Hospital. Istanbul. Turkey. kotiloglu@hotmail.com
Allergologia Et Immunopathologia
|October 22, 2008
Summary
Atopy does not influence pulmonary tuberculosis severity or cavitation. However, elevated IgE levels correlate with disseminated and cavitary tuberculosis, suggesting a dysregulated immune response.
Area of Science:
- Immunology
- Infectious Diseases
- Pulmonology
Background:
- T helper 1 (Th1) cytokines (IL-2, IFN-gamma) are crucial for antimycobacterial activity.
- Th2 immune responses characterize atopic disorders.
- Th1 and Th2 cells exhibit reciprocal negative cross-regulation.
Purpose of the Study:
- To investigate the impact of atopy on the radiological extent and disease severity of pulmonary tuberculosis (TB).
Main Methods:
- 82 male pulmonary TB patients were assessed for atopic symptoms, TB systemic symptoms, radiological dissemination, and cavitation.
- Skin prick tests (SPT) and serum total IgE levels were measured.
Main Results:
- 34.1% of patients tested positive via SPT.
- No significant difference in cavitation or radiological spread between SPT-positive and negative groups.
- Higher median IgE levels were observed in patients with moderate-severe radiological dissemination and cavitary TB.
Conclusions:
- Atopic phenotype and SPT positivity do not appear to influence TB cavitation, dissemination, or systemic symptoms.
- Elevated IgE in disseminated/cavitary TB may indicate immune dysregulation or reflect disease activity.
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