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Published on: March 1, 2013
Silicon carbide coating of nitinol stents to increase antithrombogenic properties and reduce nickel release
Jörg M Schmehl1, Claus Harder, Hans P Wendel
1Department of Diagnostic Radiology, University Hospital of Tuebingen, D-72076 Tuebingen, Germany. joerg.schmehl@med.uni-tuebingen.de
Background:
The use of stents in the superficial femoral artery is still limited by the number of restenoses. Influencing factors include thrombus formation and smooth muscle cell proliferation as well as motion stress. A reduction of thrombogenicity can be achieved by passive coating with silicon carbide, which induces less thrombus formation due to its semiconducting properties.
Methods And Materials:
Self-expanding peripheral stents with and without silicon carbide coating were examined in a chandler loop model. Assessed parameters included thrombocyte count, beta-thromboglobulin (TG), thrombin-antithrombin (TAT) III complex, and polymorphonuclear elastase. Nickel release was quantified at Days 1, 3, and 223 using graphite furnace atomic absorption spectrometry. To visualize thrombus formation on the surface, scanning electron microscopy was conducted.
Results:
The tests showed a superiority of the coated stents regarding beta-TG (484.0+/-180.2 IU/l vs 2189.1+/-898.9 IU/l) as well as formation of TAT III complex (16.0+/-19.1 microg/l vs 458.3+/-761.0 microg/l). Scanning electron microscopy revealed a nearly absent thrombus formation on the coating. Nickel release was reduced by more than 90% at all time points.
Conclusions:
In the provided in vitro setting, silicon carbide coating applied to self-expanding peripheral stents showed an advantage regarding thrombogenicity. The passive barrier resulted in a limited release of nickel from the alloy itself. These features seem promising for the use in the peripheral vasculature.
