Related Experiment Video
Updated: Jun 28, 2026

19:15
Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
Adverse neonatal outcomes: examining the risks between preterm, late preterm, and term infants
Jamie A Bastek1, Mary D Sammel, Emmanuelle Paré
1Maternal and Child Health Research Program, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
American Journal of Obstetrics and Gynecology
|October 22, 2008
Summary
Late preterm infants (34-36 weeks) face higher risks of adverse outcomes compared to full-term infants. Advancing gestational age significantly reduces these risks for preterm infants.
Area of Science:
- Neonatal outcomes
- Perinatal medicine
- Public health
Background:
- Limited data exists on neonatal outcomes for late preterm infants (34 to 36 6/7 weeks gestation).
- Understanding risks in this cohort is crucial for optimizing care.
Purpose of the Study:
- To compare adverse neonatal outcomes among infants born at 32-33 6/7 weeks, 34-36 6/7 weeks, and 37 weeks or later.
- To identify the association between gestational age and adverse neonatal outcomes.
Main Methods:
- Retrospective cohort study of 264 preterm labor patients (2002-2005).
- Inclusion criteria: delivery at 32 weeks gestation or later.
- Statistical analysis included chi-squared tests and Poisson regression to assess outcomes and control for confounders.
Main Results:
- Late preterm infants exhibit a higher incidence of adverse outcomes compared to term infants.
- Each additional week of gestational age between 32 and 39 weeks was associated with a 23% reduction in adverse outcomes (RR 0.77, P < .001).
Conclusions:
- The late preterm cohort experiences increased risks of adverse neonatal outcomes.
- Further research into obstetrical management and long-term follow-up for this population is necessary.
Related Concept Videos
Teratogenicity
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
Development of the Oral Microbiota
The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...

