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Mangafodipir trisodium-enhanced MRI of hepatocellular carcinoma: correlation with histological characteristics
1Department of Radiology, Yonsei University College of Medicine, Seoul, Republic of Korea.
Aim:
To define histopathological factors related to the degree of mangafodipir trisodium (MnDPDP) uptake in hepatocellular carcinomas (HCCs) on magnetic resonance imaging (MRI).
Materials And Methods:
In-phase and opposed-phase gradient-echo MRI images were obtained preoperatively in 37 patients with 38 HCCs before and 15-30 min after intravenous injection of MnDPDP. Subjective ratings of the enhancement degree, the signal-to-noise ratio (SNR) of the lesion and the liver, and the contrast enhancement ratios (CER) were compared with histopathological factors.
Results:
The mean SNR of HCCs increased from 59.6 to 95.0 (CER=59.5%), whereas that of the liver increased from 75.1 to 108.7 (CER=45.2%). Eight HCCs showed mild enhancement, 11 moderate enhancement, and 15 strong enhancement. There was no visually perceptible enhancement in four HCCs (10.3%). The degree of MnDPDP enhancement was significantly related with the cell density ratio (p<.05) and monoclonal hepatocyte antibody positivity (p<0.005), but not with size, growth type, cell type, histological type, cytokeratin 7, or cytokeratin 19. Well-differentiated HCC showed higher MnDPDP enhancement compared with higher grade HCCs, but the differences were not statistically significant.
Conclusion:
The uptake of MnDPDP by HCC was correlated with hepatocyte antibody expression and the cellular density ratio. Well-differentiated HCC tended to show higher MnDPDP enhancement.
Insights
Hepatocellular carcinoma (HCC) enhancement on MRI with mangafodipir trisodium (MnDPDP) correlates with hepatocyte antibody expression and cell density. Well-differentiated HCCs showed a trend toward greater MnDPDP uptake.
Area of Science:
- Radiology
- Oncology
- Pathology
Background:
- Hepatocellular carcinoma (HCC) is a common primary liver malignancy.
- Accurate assessment of HCC characteristics is crucial for treatment planning.
- Mangafodipir trisodium (MnDPDP) is an MRI contrast agent used in liver imaging.
Purpose of the Study:
- To identify histopathological factors influencing MnDPDP uptake in HCCs.
- To correlate MnDPDP enhancement patterns on MRI with specific tumor features.
Main Methods:
- Gradient-echo MRI was performed preoperatively on 37 patients with 38 HCCs.
- Images were acquired before and after intravenous MnDPDP injection.
- Enhancement degree, SNR, and CER were analyzed and compared with histopathological findings.
Main Results:
- MnDPDP significantly enhanced HCC visibility on MRI (CER=59.5%).
- Enhancement degree correlated with cell density ratio and monoclonal hepatocyte antibody positivity.
- No significant correlation was found with tumor size, growth type, or specific cytokeratin markers.
Conclusions:
- MnDPDP uptake in HCC is associated with hepatocyte antibody expression and cellular density.
- A trend towards higher MnDPDP enhancement was observed in well-differentiated HCCs.
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