Central action of nomifensine

Nomifensine, a new antidepressant drug, affects the central noradrenergic neurons in the rat. Nomifensine does not affect the noradrenaline level in the brain, but retards the depletion of noradrenaline after inhibition of its synthesis. Apomorphine and dimethylaminoadamantane accelerate the depletion of noradrenaline and amphetamine does not affect it. Nomifensine potentiates the flexor reflex of the hind paw of a spinal rat and depresses the body temperature.