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Updated: Jun 28, 2026

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
Published on: June 3, 2018
Mouse genetic models: an ideal system for understanding glaucomatous neurodegeneration and neuroprotection
Gareth R Howell1, Richard T Libby, Simon W M John
1The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
Abstract:
Here we review how mouse studies are contributing to understanding glaucoma. We include discussion of aqueous humor drainage and intraocular pressure elevation, because new treatments to avoid exposure to high pressure will indirectly protect neurons from glaucoma, and complement direct neuroprotective strategies. We describe how mouse models are adding to both the understanding of glaucomatous neurodegeneration and the development of neuroprotective strategies.
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