Related Experiment Video

Updated: Jun 28, 2026

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

Drosophila orthologues to human disease genes: an update on progress

Sergey Doronkin1, Lawrence T Reiter

  • 1Department of Neurology, Univeristy of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.

Progress in Nucleic Acid Research and Molecular Biology
|October 22, 2008
PubMed
Abstract

No abstract available in PubMed .

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Exon Recombination02:32

Exon Recombination

The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon has three reading...