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Updated: Jun 28, 2026
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Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
Published on: April 21, 2017
Perinatal arterial stroke in the preterm infant.
Manon J N L Benders1, Floris Groenendaal, Cuno S P M Uiterwaal
1Department of Neonatology, Wilhelmina Children's Hospital, UMC Utrecht, The Netherlands.
Seminars in Perinatology
|October 22, 2008
Summary
Perinatal stroke, or brain infarction, is increasingly recognized in newborns. This review highlights the scarce data on preterm infants, exploring differences in stroke incidence, presentation, and risk factors compared to full-term infants.
Area of Science:
- Neonatal neurology
- Pediatric stroke
- Neuroscience
Background:
- Neonatal seizures and neurological symptoms increasingly prompt consideration of stroke in term infants.
- Perinatal cerebral infarction has diverse etiological factors, clinical presentations, and long-term consequences.
- Existing research on perinatal arterial ischemic stroke often excludes preterm infants, leaving a data gap.
Purpose of the Study:
- To review and describe the differences between preterm and full-term infants regarding perinatal stroke.
- To elucidate potential disparities in incidence, clinical presentation, neuro-imaging, vascular distribution, and risk factors.
- To address the scarcity of data on stroke in preterm neonates.
Main Methods:
- Literature review focusing on perinatal stroke in both preterm and term infants.
- Comparative analysis of incidence, clinical manifestations, and neuro-imaging findings.
- Examination of vascular distribution patterns and identified risk factors.
Main Results:
- Data on stroke in preterm infants is scarce, with unclear reasons for this paucity.
- Differences in incidence, clinical presentation, neuro-imaging, vascular distribution, and risk factors between preterm and term infants are described.
- The review aims to consolidate existing knowledge on stroke in this vulnerable preterm population.
Conclusions:
- Perinatal stroke is not exclusive to term infants, yet preterm infant data remains limited.
- Further research is needed to understand the unique aspects of stroke in preterm neonates.
- Awareness and investigation of stroke in preterm infants are crucial for accurate diagnosis and management.
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