Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Overview of Lipid Metabolism

Overview of Lipid Metabolism

Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...

Fats as Energy Storage Molecules

Fats as Energy Storage Molecules

Triglycerides are a form of long-term energy storage molecules. They are made of glycerol and three fatty acids. To obtain energy from fat, triglycerides must first be broken down by hydrolysis into their two principal components, fatty acids and glycerol. This process, called lipolysis, takes place in the cytoplasm. The resulting fatty acids are oxidized by β-oxidation into acetyl-CoA, which is used by the Krebs cycle. The glycerol that is released from triglycerides after lipolysis directly...

Lipid Catabolism

Lipid Catabolism

Triglycerides serve as crucial long-term energy storage molecules in microorganisms, providing a dense source of metabolic energy. Their breakdown is mediated by lipases, which hydrolyze triglycerides into glycerol and free fatty acids. Each of these components follows distinct metabolic pathways, ultimately contributing to ATP synthesis and cellular energy homeostasis.Glycerol MetabolismGlycerol, released from triglyceride hydrolysis, is phosphorylated by glycerol kinase to form...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Osteoporosis medication exposure patterns and MRONJ occurrence in patients receiving romosozumab: a retrospective observational study.

Clinical oral investigations·2026

Same author

Bifacial Perovskite Solar Cells by Lamination Approach With a PEDOT:PSS/d-Sorbitol Blended Adhesion Layer.

Small methods·2026

Same author

Spatial and Molecular Progression of Neural Progenitor Cells in the Developing Human Dentate Gyrus.

bioRxiv : the preprint server for biology·2026

Same author

Dental Complications in Antithrombotic Patients: Evidence From a Nationwide Cohort and a Single-Institution Dataset.

International dental journal·2026

Same author

Progesterone induces steroidome and lipidome remodeling in a BRCA-resembling mouse model of high-grade serous ovarian cancer.

Translational oncology·2026

Same author

The impact of redox changes on uranium migration using a field tracer test and reactive transport modeling.

Journal of hazardous materials·2026

Search research articles

Related Experiment Video

Updated: Jun 28, 2026

Assessing Whole-Body Lipid-Handling Capacity in Mice

Assessing Whole-Body Lipid-Handling Capacity in Mice

Published on: November 24, 2020

Reassessing triglyceride synthesis in adipose tissue.

Colleen Nye¹, Jaeyeon Kim, Satish C Kalhan

¹Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH 44106-3549, USA.

Trends in Endocrinology and Metabolism: TEM

|October 22, 2008

Summary

Triglyceride synthesis and breakdown are vital for energy metabolism, ensuring fuel availability. Recent findings highlight re-esterification and glyceroneogenesis as key regulators of fatty acid availability, impacting metabolic health.

More Related Videos

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro

Published on: March 17, 2023

Related Experiment Videos

Last Updated: Jun 28, 2026

Assessing Whole-Body Lipid-Handling Capacity in Mice

Assessing Whole-Body Lipid-Handling Capacity in Mice

Published on: November 24, 2020

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro

Published on: March 17, 2023

Area of Science:

Metabolic biochemistry
Cellular energy regulation

Background:

Triglyceride synthesis and breakdown are central to energy metabolism, providing fuel during starvation.
Dysregulation of triglyceride turnover impacts fatty acid availability, potentially leading to insulin resistance and type 2 diabetes.
Recent research is reassessing triglyceride synthesis due to the role of fatty acid re-esterification.

Purpose of the Study:

To review recent advancements in understanding triglyceride synthesis.
To introduce glyceroneogenesis as a significant pathway in adipose tissue for glyceride-glycerol production.

Main Methods:

Literature review of recent research on triglyceride synthesis.
Analysis of the role of fatty acid re-esterification in triglyceride deposition.
Examination of the glyceroneogenesis pathway in adipose tissue.

Main Results:

Fatty acid re-esterification plays a critical role in triglyceride deposition and fatty acid availability.
Glyceroneogenesis is identified as a key regulated source of glyceride-glycerol in adipose tissue.

Conclusions:

Re-evaluation of triglyceride synthesis pathways is necessary.
Glyceroneogenesis is an important regulatory mechanism for energy metabolism in adipose tissue.