Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cardiomyopathy V: Interprofessional Care

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...

Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

Kidney Transplant I: Introduction

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A nomogram based on magnetic resonance imaging to predict perineural invasion in mass intrahepatic cholangiocarcinoma: a two-centre, retrospective study.

Clinical radiology·2025

Same author

Ventilation or aerosol extraction: comparing the efficacy of directional air purifiers, HEPA evacuators and negative-pressure environments.

The Journal of hospital infection·2024

Same author

Impact of polygenic risk score for triglyceride trajectory and diabetic complications in subjects with type 2 diabetes based on large electronic medical record data from Taiwan: a case control study.

Journal of endocrinological investigation·2024

Same author

Association of radiotherapy for prostate cancer and second primary colorectal cancer: a US population-based analysis.

Techniques in coloproctology·2023

Same author

Age-related genes affecting the immune cell infiltration in ulcerative colitis revealed by weighted correlation network analysis and machine learning.

European review for medical and pharmacological sciences·2023

Same author

Zoledronic acid epigenetically alleviates high-glucose-suppressed osteogenic differentiation of MC3T3-E1 cells.

European review for medical and pharmacological sciences·2023

Search research articles

Related Experiment Video

Updated: Jun 28, 2026

A Modified Cuff Technique for Mouse Cervical Heterotopic Heart Transplantation Model

A Modified Cuff Technique for Mouse Cervical Heterotopic Heart Transplantation Model

Published on: February 7, 2022

Updates in heart transplantation.

J Wei¹, C-Y Chang, Y-C Chuang

¹Heart Center, Cheng-Hsin General Hospital, Cheng-Hsin Rehabilitation Medical Center, Taipei, Taiwan, R.O.C. jengwei@mac.com

Transplantation Proceedings

|October 22, 2008

Summary

This summary is machine-generated.

Heart transplantation (HTx) offers successful therapy for end-stage heart failure. This study shows satisfactory short- and long-term outcomes using low-dose immunosuppression and biatrial anastomosis, expanding the donor pool with suboptimal hearts.

More Related Videos

A Porcine Heterotopic Heart Transplantation Protocol for Delivery of Therapeutics to a Cardiac Allograft

A Porcine Heterotopic Heart Transplantation Protocol for Delivery of Therapeutics to a Cardiac Allograft

Published on: February 14, 2022

Cardiac Loading using Passive Left Atrial Pressurization and Passive Afterload for Graft Assessment

Cardiac Loading using Passive Left Atrial Pressurization and Passive Afterload for Graft Assessment

Published on: August 2, 2024

Related Experiment Videos

Last Updated: Jun 28, 2026

A Modified Cuff Technique for Mouse Cervical Heterotopic Heart Transplantation Model

A Modified Cuff Technique for Mouse Cervical Heterotopic Heart Transplantation Model

Published on: February 7, 2022

A Porcine Heterotopic Heart Transplantation Protocol for Delivery of Therapeutics to a Cardiac Allograft

A Porcine Heterotopic Heart Transplantation Protocol for Delivery of Therapeutics to a Cardiac Allograft

Published on: February 14, 2022

Cardiac Loading using Passive Left Atrial Pressurization and Passive Afterload for Graft Assessment

Cardiac Loading using Passive Left Atrial Pressurization and Passive Afterload for Graft Assessment

Published on: August 2, 2024

Area of Science:

Cardiology
Transplantation Surgery
Immunology

Background:

Heart transplantation (HTx) is a life-saving treatment for end-stage heart failure.
Mechanical circulatory support and advanced immunosuppression strategies are crucial for patient management.
Optimizing donor organ utilization is essential to address organ shortages.

Purpose of the Study:

To evaluate the long-term outcomes of heart transplantation using a specific immunosuppression protocol.
To assess the efficacy of using suboptimal donor hearts to expand the donor pool.
To analyze the results of the biatrial anastomotic technique in heart transplantation.

Main Methods:

Retrospective analysis of 288 heart transplantations performed since 1987.
Utilized anti-thymocyte globulin (ATG) for induction and low-dose immunosuppressants for maintenance.
Employed the standard biatrial anastomotic technique, including cases with suboptimal donor hearts and 14-day total artificial heart (TAH) bridging.

Main Results:

Actuarial survival rates at 1, 5, and 10 years were 86%, 76%, and 61%, respectively.
Demonstrated satisfactory outcomes with suboptimal donor hearts and successful combined heart-kidney transplant with TAH bridging.
Observed no increased incidence of tricuspid regurgitation or conduction disturbances compared to the bicaval technique.

Conclusions:

Low-dose immunosuppressive therapy combined with the biatrial technique yields satisfactory short- and long-term results in heart transplantation.
The use of suboptimal donor hearts can expand the donor pool and improve patient survival.
The biatrial anastomosis technique remains a reliable surgical approach for heart transplantation.