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[Membranous nephritis after renal transplantation]
N R Robles1, F Gómez Campdera, F Anaya
1Servicio de Nefrología, Hospital General Gregorio Marañón, Madrid.
Anales De Medicina Interna (Madrid, Spain : 1984)
|February 1, 1991
Summary
Membranous glomerulonephritis (MG) is an infrequent complication following renal transplantation (RT), typically presenting benign outcomes. Post-transplant urologic issues may increase the risk of developing new-onset MG.
Area of Science:
- Nephrology
- Transplant Immunology
Background:
- Membranous glomerulonephritis (MG) is a significant cause of nephrotic syndrome in adults.
- Renal transplantation (RT) is a life-saving procedure for end-stage renal disease, but post-transplant complications can arise.
Observation:
- This study presents 8 cases of membranous glomerulonephritis (MG) after renal transplantation (RT).
- The overall incidence of MG post-transplant was 1.63%, with 1.39% representing new cases.
- Most patients maintained renal function, except one with MG and chronic rejection.
Findings:
- Proteinuria onset ranged from 2 to 23 months post-RT, with nephrotic-range proteinuria in 4 cases.
- No associations were found with neoplasias, specific drugs, or chronic infections (except one Hepatitis B antigen carrier).
- Six patients experienced post-transplant urological complications, including urinary fistulas and obstructive uropathy.
Implications:
- Membranous glomerulonephritis is a rare but recognized complication of renal transplantation.
- Patients with post-transplant urological complications may face an elevated risk of developing de novo MG.
- Early detection and management of MG post-RT are crucial for graft survival and patient outcomes.